Microscopes were invented almost four hundred years ago. But today, there's a revolution in microscopy (as in so many other fields) associated with computation. We've been working hard to make the Wolfram Language a definitive platform for the emerging field of computational microscopy. It all starts with getting an image of some kind---whether from a light or x-ray microscope, transmission electron microscope (TEM), confocal laser scanning microscope (CLSM), two-photon excitation or a scanning electron microscope (SEM), as well as many more. You can then proceed to enhance images, reconstruct objects and perform measurements, detection, recognition and classification. At last month's Microscopy & Microanalysis conference, we showed various examples of this pipeline, starting with a Zeiss microscope and a ToupTek digital camera.