Wolfram Computation Meets Knowledge

Date Archive: 2015 January


MHacks V’s Winning Hack Uses Wolfram Programming Cloud

Draw Anything, an iOS app designed and created by Olivia Walch and Matt Jacobs, was the winning hack at the recent MHacks V. Utilizing the power of Wolfram Programming Cloud, the two Draw Anything hackers came out on top after a fierce competition between more than 250 talented teams, made up of 1,200 hackers representing over 100 universities. Students from around the world came to learn, network, and "spend 36 hours building anything they can imagine."
Education & Academic

Jacob Bernoulli’s Legacy in Mathematica

January 16, 2015, marks the 360th birthday anniversary of Jacob Bernoulli (also James, or Jacques). Jacob Bernoulli was the first mathematician in the Bernoulli family, which produced many notable mathematicians of the seventeenth and eighteenth centuries. Jacob Bernoulli's mathematical legacy is rich. He introduced Bernoulli numbers, solved the Bernoulli differential equation, studied the Bernoulli trials process, proved the Bernoulli inequality, discovered the number e, and demonstrated the weak law of large numbers (Bernoulli's theorem).

A Mathematical Modeling Approach to Monitoring Liver Function in Drug Trials

Explore the contents of this article with a free Wolfram SystemModeler trial. Mathematical modeling is not just used for understanding and designing new products and drugs; modeling can also be used in health care, and in the future, your doctor might examine your liver with a mathematical model just like the one researchers at AstraZeneca have developed. The liver is a vital organ, and currently there isn't really a way to compensate for loss of liver function in the long term. The liver performs a wide range of functions, including detoxification, protein synthesis, and secretion of compounds necessary for digestion, just to mention a few. In the US and Europe, up to 15 % of all acute liver failure cases are due to drug-induced liver injury, and the risk of injuring the liver is of major concern in testing new drug candidates. So in order to safely monitor the impact of a new drug candidate on the liver, researchers at the pharmaceutical company AstraZeneca have recently published a method for evaluating liver function that combines magnetic resonance imaging (MRI) and mathematical modeling---potentially allowing for early identification of any reduced liver function in humans. Last year, Wolfram MathCore and AstraZeneca worked together on a project where we investigated some modifications of AstraZeneca's modeling framework. We presented the promising results at the ISMRM-ESMRMB Joint Annual Meeting, which is the major international magnetic resonance conference. In this blog post, I'll show how the Wolfram Language was used to calculate liver function and how more complex models of liver function can be implemented in Wolfram SystemModeler.